The Acute Toxicity of The Organ phosphorus Dimethoate to Male and Female Swiss Albino Mice, Mus musculus

Dimethoate is among the most used organophosphorus ( OP ) in agriculture and public health pest control. The compound was classified as a moderately toxic to mammals and accidental poisoning in human is very common. The objective of the present work was to further evaluate dimethoate acute toxicity as well as its effects on body weight change and some blood parameters of male and female swiss albino mice, Mus masculaus. The LD50 of dimethoate to female mice was 134.5 mg/kg and hence was considered as moderately toxic. No significant change in body weight of male or female exposed to 24 and 38 mg/kg dimethoate as compared to control groups after 10 weeks of experiment. The mean values for male body weight were 31.39, 31.18 and 32.71 gm for control, 24 mg/kg and 38 mg/kg dimethoate treated, respectively. Whereas, body weight for female were 32.09, 31.82 and 32.09 gm for control, 24 mg/kg and 38 mg/kg dimethoate respectively. Treated males and females WBC and RBC showed higher values in both the 24 and 38 compared to control group. The Hb values of 24 and 38 mg/kg dimethoate treated males were comparable or slightly higher as compared to control. Whereas, the same parameters of the treated females showed higher values in both doses as compared to control.